Efecto de la adición del nopal (Opuntia ficus-indica) a la dieta de ratas diabéticas sobre niveles séricos de glucosa y citoarquitectura pancreática

Cinthia M. González Borja; Manuel López Rodríguez; Rosa Elena Pérez Sánchez; Ramiro Escudero García; Daniel Val Arreola; Juvenal Esquivel Córdova; Ruy Ortiz Rodríguez

doi:10.35830/cn.vi95.826

Effect of adding nopal (Opuntia ficus-indica) to the diet of rats with induced diabetes on serum glucose levels and pancreatic cytoarchitecture

Authors

Cinthia M. González Borja Facultad de Químico Farmacobiología, UMSNH
Manuel López Rodríguez Facultad de Medicina Veterinaria y Zootecnia, UMSNH
Rosa Elena Pérez Sánchez Facultad de Químico Farmacobiología
Ramiro Escudero García Instituto de Investigación en Metalurgía y Materiales, UMSNH
Daniel Val Arreola Instituto de Investigaciones Agropecuarias y Forestales, Universidad Michoacana de San Nicolás de Hidalgo.
Juvenal Esquivel Córdova Facultad de Agrobiología “Presidente Juárez”, Universidad Michoacana de San Nicolás de Hidalgo.
Ruy Ortiz Rodríguez Facultad de Medicina Veterinaria y Zootecnia, UMSNH

DOI:

https://doi.org/10.35830/cn.vi95.826

Keywords:

Insulitis, inducción, células β, aloxano

Abstract

Type I diabetes mellitus (DM) develops from the destruction of pancreatic β-cells; destruction caused by chronic exposure to proinflammatory cytokines and auto-reactive immune cells (insulitis) that together cause pancreatic β-cell death and induce the clinical symptoms of DM. However, in patients with type I DM it has been demonstrated that β-cells can respond to the immune attack -as an adaptive molecular mechanism- but not in type II DM. This aspect could be evidenced in this research (increase in the β-cell population) by establishing not only the dynamics of serum glucose levels but also the pancreatic cytoarchitecture of DM-induced rats subjected to a treatment of insulin plus diet added with nopal cactus.

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Published

2025-12-03

How to Cite

González Borja, C. M., López Rodríguez , M., Pérez Sánchez, R. E., Escudero García, R., Val Arreola, D., Esquivel Córdova, J., & Ortiz Rodríguez, R. (2025). Effect of adding nopal (Opuntia ficus-indica) to the diet of rats with induced diabetes on serum glucose levels and pancreatic cytoarchitecture. Ciencia Nicolaita, (95), 92–100. https://doi.org/10.35830/cn.vi95.826

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Issue

No. 95 (2025)

Section

Biotecnología y Ciencias Agropecuarias

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This work is licensed under a Creative Commons Attribution-NoDerivatives 4.0 International License.

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